Generic Buspar (Buspirone)
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Generic Buspar (Buspirone) Hydrochloride is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety. Generic Buspar (Buspirone) is an agent that is not chemically or pharmacologically related to the benzodiazepines (e.g. Valium, Xanax) barbituates, or other sedative/anti-anxiety drugs.
Generic Buspar (Buspirone) tablets come in 5mg, 10mg, 15mg and 30mg strengths.
HOW DOES Generic Buspar (Buspirone) WORK?
The mechanism of action of Generic Buspar (Buspirone) is not clearly known. Generic Buspar (Buspirone) differs from typical benzodiazepines like Vallium or Xanax anti-anxiety medication in that Generic Buspar (Buspirone) does not exert anti-seizure or muscle relaxant effects. Generic Buspar (Buspirone) also lacks the prominent sedative effect that is associated with benzodiazepines
In vitro studies have shown that Generic Buspar (Buspirone) has a high affinity for serotonin receptors (receptors in the brain that mediate arousal). Generic Buspar (Buspirone) has no significant affinity for benzodiazepine receptors in the brain.
HOW EFFECTIVE IS Generic Buspar (Buspirone)
The excellent efficacy of Generic Buspar (Buspirone) has been demonstrated in controlled clinical trials of outpatients with a diagnosis of Generalized Anxiety Disorder (GAD).
The patients evaluated in these studies had experienced symptoms for periods of 1 month to over 1 year prior to the study, with an average symptom duration of 6 months. Generalized, persistent anxiety (of at least one month continual duration), manifested by symptoms from three of the four following categories :
Motor tension: Shakiness, jitteriness, jumpiness, trembling, tension, muscle aches, fatigability, inability to relax, eyelid twitch, furrowed brow, strained face, fidgeting, restlessness, easy startle.
Autonomic hyperactivity: Sweating, heart pounding or racing, cold, clammy hands, dry mouth, dizziness, lightheadedness, paresthesias (tingling in hands or feet), upset stomach, hot or cold spells, frequent urination, diarrhea, discomfort in the pit of the stomach, lump in the throat, flushing, pallor, high resting pulse and respiration rate.
Apprehensive expectation: Anxiety, worry, fear, rumination, and anticipation of misfortune to self or others.
Vigilance and scanning: Hyper-attentiveness resulting in distractibility, difficulty in concentrating, insomnia, feeling "on edge", irritability, impatience.
The effectiveness of Generic Buspar (Buspirone) in long-term use, that is, for more than 3 to 4 weeks, has not been demonstrated in controlled trials. There is no body of evidence available that systematically addresses the appropriate duration of treatment for GAD. However, in a study of long-term use of Generic Buspar (Buspirone), 264 patients were treated with Generic Buspar (Buspirone) for 1 year without ill effect. Therefore, the physician who elects to use Generic Buspar (Buspirone) for extended periods should periodically reassess the usefulness of the drug for the individual patient.
Generic Buspar (Buspirone) DOSAGE AND ADMINISTRATION :
The recommended initial dose of Generic Buspar (Buspirone) is 15 mg daily (5 mg 3 times a day). To achieve an optimal therapeutic response, at intervals of 2 to 3 days the Generic Buspar (Buspirone) dosage may be increased 5 mg per day, as needed. The maximum daily dosage of Generic Buspar (Buspirone) should not exceed 60 mg per day. In clinical trials allowing dose titration, divided doses of 20 to 30 mg per day were commonly employed.
Generic Buspar (Buspirone) ADVERSE REACTIONS
The more commonly observed untoward events associated with the use of Generic Buspar (Buspirone) not seen at an equivalent incidence among placebo-treated patients include dizziness, nausea, headache, nervousness, lightheadedness, and excitement.
Other common adverse events associated with Generic Buspar (Buspirone) included: central nervous system disturbances (3.4%), primarily dizziness, insomnia, nervousness, drowsiness, and lightheaded feeling; gastrointestinal disturbances (1.2%), primarily nausea; and miscellaneous disturbances (1.1%), primarily headache and fatigue.
Generic Buspar (Buspirone) interference with cognitive and motor performance: Studies indicate that Generic Buspar (Buspirone) is less sedating than other anti-anxiety medications and that Generic Buspar (Buspirone) does not produce significant functional impairment. However, Generic Buspar (Buspirone) CNS effects in any individual patient may not be predictable.
Therefore, patients should be cautioned about operating an automobile or using complex machinery until they are reasonably certain that Generic Buspar (Buspirone) treatment does not affect them adversely.
While formal studies of the interaction of Generic Buspar (Buspirone) with alcohol indicate that Generic Buspar (Buspirone) does not increase alcohol-induced impairment in motor and mental performance, Generic Buspar (Buspirone) is prudent to avoid concomitant use of alcohol and Generic Buspar (Buspirone).
Generic Buspar (Buspirone) DRUG ABUSE AND Generic Buspar (Buspirone) DEPENDENCE :
In human and animal studies, Generic Buspar (Buspirone) has shown no potential for abuse or diversion and there is no evidence that it causes tolerance, or either physical or psychological dependence. Human volunteers with a history of recreational drug or alcohol usage were studied in two double-blind clinical investigations. None of the subjects were able to distinguish between Generic Buspar (Buspirone) and placebo. In addition, studies in monkeys, mice, and rats have indicated that Generic Buspar (Buspirone) lacks potential for abuse.
Although there is no direct evidence that Generic Buspar (Buspirone) causes physical dependence or drug-seeking behavior, it is difficult to predict from experiments the extent to which a CNS-active drug will be misused.
BE SURE TO INCLUDE IN YOUR PHYSCIAL EXAMINATION/MEDICAL QUESTIONAIRRE FORM THE FOLLOWING INFORMATION :
Include any medications, prescription or non-prescription, alcohol, or drugs that you are now taking or plan to take during your treatment with Generic Buspar (Buspirone).
Note if you are pregnant, or if you are planning to become pregnant while you are taking Generic Buspar (Buspirone).
Note if you are breast-feeding an infant.
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